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© Institut Pasteur/Antoinette Ryter
Salmonella spp. Bactéries à Gram négatif, aérobies ou anaérobies facultatifs à transmission orofécale. Les salmonelles majeures (sérotype typhi et sérotype paratyphi) sont responsables des fièvres typhoïde et paratyphoïde chez l'homme uniquement ; les salmonelles mineures (sérotype typhimurium et sérotype enteritidis) sont impliquées dans 30 à 60 % des gastroentérites et toxiinfections d'origine alimentaire. Image colorisée.
Publication : Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Ocular penetration of linezolid after oral administration in rabbits

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics - 21 Apr 2011

Saleh M, Lefevre S, Bourcier T, Prevost G, Gaucher D, Speeg-Schatz C, Jehl F

Link to Pubmed [PMID] – 21510740

J Ocul Pharmacol Ther 2011 Jun;27(3):243-6

PURPOSE: The pharmacokinetics of linezolid (LZD) was investigated in rabbit eyes after single and multiple oral administrations.

SETTING: Pharmacology Laboratory, University Hospital of Strasbourg, Strasbourg, France.

METHODS: Twelve New Zealand rabbits were divided into 2 groups: an oral dose of 120 mg (35 mg/kg) was administrated in group 1 (n=6), and a multiple-dose protocol targeting the steady state (120 mg twice a day for 3 days) was given in group 2 (n=6). Serum (s) and vitreous (v) samples were collected after 0, 30, and 45 min and after 1, 2, 4, 6, 8, and 12 h. LZD concentrations were measured by high-performance liquid chromatography.

RESULTS: LZD exhibited a mean C(max) in serum of 13.9±4.5 (standard deviation) mg/L after a T(max) of 1 h in group 1 and 18.0±6.5 mg/L after a T(max) of 30 min in group 2. The vitreal peak occurred at 2 h in both groups with an intraocular C(max) of 3.0±1.3 mg/L in group 1 and 4.5±1.4 mg/L in group 2. The resulting area under the concentration-time curve in vitreous at the steady state compared with the area under the concentration-time curve calculated after a single dose increased significantly (28.7±7.7 vs. 18.3±2.1 mg·h/L, respectively, pMIC) in group 2 was eventually >40% for MIC up to 3 mg/L in rabbit vitreous.

CONCLUSIONS: Although a single oral dose produced intraocular concentrations barely sufficient to induce bacterial eradication, a multiple-dose regimen provided intraocular levels exceeding the MICs of most Gram-positive organisms responsible for endophthalmitis.

https://www.ncbi.nlm.nih.gov/pubmed/21510740