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© Research
Publication : Current opinion in cell biology

Nutrient control of neural stem cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in cell biology - 17 Sep 2011

Spéder P, Liu J, Brand AH

Link to Pubmed [PMID] – 21930368

Curr. Opin. Cell Biol. 2011 Dec;23(6):724-9

The physiological status of an organism is able to influence stem cell behaviour to ensure that stem cells meet the needs of the organism during growth, and in response to injury and environmental changes. In particular, the brain is sensitive to metabolic fluctuations. Here we discuss how nutritional status is able to regulate systemic and local insulin/IGF signalling so as to control aspects of neural stem behaviour. Recent results have begun to reveal how systemic signals are relayed to neural stem cells through local interactions with a glial niche. Although much still remains to be discovered, emerging parallels between the regulation of Drosophila and mammalian stem cells suggest a conserved mechanism for how the brain responds to changes in nutritional state.

http://www.ncbi.nlm.nih.gov/pubmed/21930368