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© Research
Publication : International immunology

New synthetic analogs of lipid A as lipopolysaccharide agonists or antagonists of B lymphocyte activation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 01 Apr 1992

Pedron T, Girard R, Eustache J, Bulusu AR, Macher I, Radzyner-Vyplel H, Stütz PL, Chaby R

Link to Pubmed [PMID] – 1591221

Int. Immunol. 1992 Apr;4(4):533-40

We have studied the ability of synthetic analogs of lipid A to mimic lipopolysaccharide (LPS) for activation of 70Z/3 pre-B cells (expression of surface Igs) or to antagonize this effect. The results indicate that the presence of glucosamine (mono- or disaccharide) as a ‘backbone’ for the attachment of fatty acids is not necessary for activation of cells of the B lineage. Phosphate groups are not necessary either. Other structural features such as the configuration of particular asymmetric carbons, and the distance between an anionic group and an N-acyl chain, seem to be much more critical parameters for activation of B cells. Among the synthetic lipids which were unable to activate 70Z/3 cells, one compound, consisting of N,N-acylated and bisphosphorylated 2,3-dideoxy-2,3-diamino-D-glucose, behaved as a specific LPS antagonist and blocked also the activation triggered by the other synthetic inducers. The influence of the synthetic lipids on the entry of mature mouse B lymphocytes into the G1A phase of the cell cycle (cell enlargement) was also investigated. A high correlation was observed between the potency to activate pre-B cells and the ability to induce blast formation in mature B cells.

http://www.ncbi.nlm.nih.gov/pubmed/1591221