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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : Clinics in chest medicine

Neuroanatomy and Physiology of Brain Dysfunction in Sepsis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinics in chest medicine - 01 Jun 2016

Mazeraud A, Pascal Q, Verdonk F, Heming N, Chrétien F, Sharshar T

Link to Pubmed [PMID] – 27229649

Clin. Chest Med. 2016 06;37(2):333-45

Sepsis-associated encephalopathy (SAE), a complication of sepsis, is often complicated by acute and long-term brain dysfunction. SAE is associated with electroencephalogram pattern changes and abnormal neuroimaging findings. The major processes involved are neuroinflammation, circulatory dysfunction, and excitotoxicity. Neuroinflammation and microcirculatory alterations are diffuse, whereas excitotoxicity might occur in more specific structures involved in the response to stress and the control of vital functions. A dysfunction of the brainstem, amygdala, and hippocampus might account for the increased mortality, psychological disorders, and cognitive impairment. This review summarizes clinical and paraclinical features of SAE and describes its mechanisms at cellular and structural levels.

https://www.ncbi.nlm.nih.gov/pubmed/27229649