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© Research
Publication : Cell

Multiscale Structuring of the E. coli Chromosome by Nucleoid-Associated and Condensin Proteins

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell - 10 Jan 2018

Lioy VS*, Cournac A*, Marbouty M, Duigou S, Mozziconacci J, Espéli O, Boccard F, Koszul R

Link to Pubmed [PMID] – 29358050

Cell 2018 Jan;

As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally toward the opposite terminus region. Here, we investigate the higher-order architecture of the Escherichia coli genome, showing its partition into two structurally distinct entities by a complex and intertwined network of contacts: the replication terminus (ter) region and the rest of the chromosome. Outside of ter, the condensin MukBEF and the ubiquitous nucleoid-associated protein (NAP) HU promote DNA contacts in the megabase range. Within ter, the MatP protein prevents MukBEF activity, and contacts are restricted to ∼280 kb, creating a domain with distinct structural properties. We also show how other NAPs contribute to nucleoid organization, such as H-NS, which restricts short-range interactions. Combined, these results reveal the contributions of major evolutionarily conserved proteins in a bacterial chromosome organization.

https://www.ncbi.nlm.nih.gov/pubmed/29358050