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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Bulletin de la Societe de pathologie exotique (1990)

[Multiple and successive treatment failures in a patient infected by Plasmodium falciparum in Cambodia and treated by dihydroartemisinin-piperaquine]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bulletin de la Societe de pathologie exotique (1990) - 06 Apr 2016

Witkowski B, Khim N, Kim S, Domergue A, Duru V, Menard D

Link to Pubmed [PMID] – 27100863

Bull Soc Pathol Exot 2016 May;109(2):87-90

Cases of treatment failures following administration of artemisinin-based combination therapies (ACT) remain rare in malaria endemic areas. In Cambodia, however, failures of these treatments are now commonly observed. Usually, these post-treatment recurrences occur only once and a second course of the same treatment is sufficient to cure patients.We describe here an atypical case of a Plasmodium falciparum-infected patient manifesting several malaria recrudescence episodes following dihydroartemisinin-piperaquine (Eurartesim®) treatment. This case report illustrates the current issue of resistance to the latest generation of antimalarial drugs in Southeast Asia and highlights the difficulty in efficaciously fighting malaria in this region if new therapy remains unimplemented.

https://www.ncbi.nlm.nih.gov/pubmed/27100863