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© Research
Publication : PloS one

Multiple advantageous amino acid variants in the NAT2 gene in human populations

Team: Human Evolutionary Genetics
Member: Lluis Quintana-Murci
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 05 Sep 2008

Luca F, Bubba G, Basile M, Brdicka R, Michalodimitrakis E, Rickards O, Vershubsky G, Quintana-Murci L, Kozlov AI, Novelletto A

Link to Pubmed [PMID] – 18773084

PLoS ONE 2008;3(9):e3136

Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety of drugs of therapeutic use. Here, we explore the pattern of genetic variation in 12 human populations that significantly extend the geographic range and resolution of previous surveys, to test the hypothesis that different dietary regimens and lifestyles may explain inter-population differences in NAT2 variation.