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© Research
Publication : Science (New York, N.Y.)

Molecular to organismal chirality is induced by the conserved myosin 1D

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 23 Nov 2018

Lebreton G, Géminard C, Lapraz F, Pyrpassopoulos S, Cerezo D, Spéder P, Ostap EM, Noselli S

Link to Pubmed [PMID] – 30467170

Science 2018 11;362(6417):949-952

The emergence of asymmetry from an initially symmetrical state is a universal transition in nature. Living organisms show asymmetries at the molecular, cellular, tissular, and organismal level. However, whether and how multilevel asymmetries are related remains unclear. In this study, we show that myosin 1D (Myo1D) and myosin 1C (Myo1C) are sufficient to generate de novo directional twisting of cells, single organs, or the whole body in opposite directions. Directionality lies in the myosins’ motor domain and is swappable between Myo1D and Myo1C. In addition, Myo1D drives gliding of actin filaments in circular, counterclockwise paths in vitro. Altogether, our results reveal the molecular motor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton.

https://www.ncbi.nlm.nih.gov/pubmed/30467170