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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie

Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig

Team: Human Genetics and Cognitive Functions
Team: Integrative Neurobiology of Cholinergic Systems
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 01 Jan 1992

Weydert A, Cloez-Tayarani I, Fillion MP, Simon-Chazottes D, Guenet JL, Fillion G

Link to Pubmed [PMID] – 1521164

C. R. Acad. Sci. III, Sci. Vie 1992;314(10):429-35

The G protein coupled serotonin (5-HT) receptors, with seven membrane spanning domains, form a multigene family of which several members have been cloned and sequenced. The presence of 5-HT1D binding sites to our knowledge has not yet been reported in mouse. Here we describe the cloning and sequencing by the polymerase chain reaction (PCR) method of two 5-HT1D receptor sequences of the third cytoplasmic loop in mouse, strongly suggesting the existence of two 5-HT1D receptor genes, located on chromosome 4. A homologous sequence to one of them was cloned in guinea pig.