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© Pierre Gounon
Virus influenza purifié, agent de la grippe. Ce virus enveloppé possède un génome fragmenté : 8 segments d'ARN négatif protégés par une nucléocapside.
Publication : PloS one

Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics.

Team: Environment and Infectious Risks
Member: Christophe Batejat
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 01 Jan 2019

Obam Mekanda FM, Monamele CG, Simo Nemg FB, Yonga GM, Ouapi D, Penlap Beng V, Batéjat C, Caro V, Manuguerra JC, Demanou M,

Link to Pubmed [PMID] – 31553766

Link to DOI – 10.1371/journal.pone.0222428

PLoS One 2019 ; 14(9): e0222428

The first genotyping data on measles virus (MeV) strains in Cameroon dates from 1994, while other studies were realized in 2001 and 2011 with the establishment of MeV virological surveillance. However, the genetic data of MeV strains circulating in Cameroon remains fragmented and concentrated in certain regions, hence the need for an update. The objective of this study was to have recent data on MeV genotypes circulating in Cameroon. Ninety throat swabs collected during recent measles outbreaks were analyzed by MeV genotyping RT-PCR using the nucleoprotein gene N. The resulting sequences were analyzed on the basis of 450 nucleotides with MEGA 7 software. Overall genome analysis was performed on 40/90 sequences. The strains were from all ten regions and all belonged to cluster 1 of genotype B3. The genotype B3 has been circulating in Cameroon for long periods of time; efforts must be made in immunization for its elimination.