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© Research
Publication : PLoS neglected tropical diseases

MicroRNA expression profile in human macrophages in response to Leishmania major infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS neglected tropical diseases - 03 Oct 2013

Lemaire J, Mkannez G, Guerfali FZ, Gustin C, Attia H, Sghaier RM, , Dellagi K, Laouini D, Renard P

Link to Pubmed [PMID] – 24098824

PLoS Negl Trop Dis 2013;7(10):e2478

Leishmania (L.) are intracellular protozoan parasites able to survive and replicate in the hostile phagolysosomal environment of infected macrophages. They cause leishmaniasis, a heterogeneous group of worldwide-distributed affections, representing a paradigm of neglected diseases that are mainly embedded in impoverished populations. To establish successful infection and ensure their own survival, Leishmania have developed sophisticated strategies to subvert the host macrophage responses. Despite a wealth of gained crucial information, these strategies still remain poorly understood. MicroRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide non-coding RNAs, are described to participate in the regulation of almost every cellular process investigated so far. They regulate the expression of target genes both at the levels of mRNA stability and translation; changes in their expression have a profound effect on their target transcripts.

http://www.ncbi.nlm.nih.gov/pubmed/24098824