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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : Current opinion in immunology

Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 24 Jun 2019

Escoll P, Buchrieser C

Link to Pubmed [PMID] – 31247377

Curr. Opin. Immunol. 2019 Jun;60:117-123

The limited metabolic resources of a cell represent an intriguing ‘conflict of interest’ during host-pathogen interactions, as the battle for nutrients might determine the outcome of an infection. To adapt their metabolic needs, innate immune cells such as monocytes, macrophages or dendritic cells reprogram their metabolism upon activation by microbial compounds. In turn, infection by intracellular bacteria provokes metabolic alterations of the host cell that benefit the pathogen. Here, we discuss the state-of-the-art knowledge on metabolic reprogramming of host cells upon activation or infection with intracellular bacteria. The study of the host-driven and pathogen-driven metabolic alterations that seem to co-exist during infection is an emerging field that will define the metabolic pathways that might be targeted to combat infection.

https://www.ncbi.nlm.nih.gov/pubmed/31247377