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© Research
Publication : Cellular and molecular life sciences : CMLS

Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata

Team: Spatial Regulation of Genomes
Member: Agnès Thierry
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular and molecular life sciences : CMLS - 28 Nov 2009

Thierry A, Dujon B, Richard GF

Link to Pubmed [PMID] – 19946728

Cell. Mol. Life Sci. 2010 Mar;67(5):671-6

Megasatellites are DNA tandem arrays made of large motifs; they were discovered in the yeast Candida glabrata. They are widespread in this species (40 copies) but are not found in any other hemiascomycete so far, raising the intriguing question of their origin. They are found mainly in genes encoding cell wall products, suggesting that megasatellites were selected for a function linked to cell-cell adhesion or to pathogenicity. Their putative role in promoting genome rearrangements by interfering with DNA replication will also be discussed.