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© Research
Publication : Kardiologiia

[Mechanism of action of adenosine on intracellular calcium and platelet aggregation]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Kardiologiia - 01 Nov 1991

Feoktistov IA, Pol S, Khollister AS, Robertson D, Biadzhoni I

Link to Pubmed [PMID] – 1666665

Kardiologiia 1991 Nov;31(11):76-9

Adenosine inhibits platelet aggregation and elevates the levels of cytoplasmic Ca2+ induced by thrombin, 0.3 U/ml). When given at the maximal (100 microM) concentration, adenosine completely inhibits the aggregation, but only partially (by 55%) suppresses the growth of Ca2+, blocking both its entry and intracellular depot mobilization. Adenosine is likely to affect intracellular Ca2+, by activating adenylate cyclase, since 2′,5′-didesoxyadenosine (1 mM) prevents the effect of adenosine, by inhibiting the enzyme, whereas the phosphodiesterase inhibitor papaverine (1 microM) potentiates its effect. When stimulated with adrenaline, 1 microM, adenosine and dibutyryl-cAMP are also able to inhibit platelet aggregation in the absence of cytoplasmic Ca2+ growth.

https://www.ncbi.nlm.nih.gov/pubmed/1666665