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© Institut Pasteur
Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).
Publication : Current opinion in microbiology

Living with the enemy: viral persistent infections from a friendly viewpoint

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 05 Jul 2012

Goic B, Saleh MC

Link to Pubmed [PMID] – 22770658

Curr. Opin. Microbiol. 2012 Aug;15(4):531-7

Persistent infection is a situation of metastability in which the pathogen and the host coexist. A common outcome for viral infections, persistence is a widespread phenomenon through all kingdoms. With a clear benefit for the virus and/or the host at the population level, persistent infections act as modulators of the ecosystem. The origin of persistence being long time elusive, here we explore the concept of ‘endogenization’ of viral sequences with concomitant activation of the host immune pathways, as a main way to establish and maintain viral persistent infections. Current concepts on viral persistence mechanisms and biological role are discussed.

http://www.ncbi.nlm.nih.gov/pubmed/22770658