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© Research
Publication : BMC developmental biology

KIT is required for hepatic function during mouse post-natal development

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC developmental biology - 05 Jul 2007

Magnol L, Chevallier MC, Nalesso V, Retif S, Fuchs H, Klempt M, Pereira P, Riottot M, Andrzejewski S, Doan BT, Panthier JJ, Puech A, Beloeil JC, de Angelis MH, Hérault Y

Link to Pubmed [PMID] – 17612398

BMC Dev. Biol. 2007;7:81

The Kit gene encodes a receptor tyrosine kinase involved in various biological processes including melanogenesis, hematopoiesis and gametogenesis in mice and human. A large number of Kit mutants has been described so far showing the pleiotropic phenotypes associated with partial loss-of-function of the gene. Hypomorphic mutations can induce a light coat color phenotype while complete lack of KIT function interferes with embryogenesis. Interestingly several intermediate hypomorphic mutations induced in addition growth retardation and post-natal mortality.

http://www.ncbi.nlm.nih.gov/pubmed/17612398