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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : The Journal of cell biology

Katanin regulates dynamics of microtubules and biogenesis of motile cilia

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of cell biology - 10 Sep 2007

Sharma N, Bryant J, Wloga D, Donaldson R, Davis RC, Jerka-Dziadosz M, Gaertig J

Link to Pubmed [PMID] – 17846175

J. Cell Biol. 2007 Sep;178(6):1065-79

The in vivo significance of microtubule severing and the mechanisms governing its spatial regulation are not well understood. In Tetrahymena, a cell type with elaborate microtubule arrays, we engineered null mutations in subunits of the microtubule-severing complex, katanin. We show that katanin activity is essential. The net effect of katanin on the polymer mass depends on the microtubule type and location. Although katanin reduces the polymer mass and destabilizes the internal network of microtubules, its activity increases the mass of ciliary microtubules. We also show that katanin reduces the levels of several types of post-translational modifications on tubulin of internal and cortical microtubules. Furthermore, katanin deficiencies phenocopy a mutation of beta-tubulin that prevents deposition of polymodifications (glutamylation and glycylation) on microtubules. We propose that katanin preferentially severs older, post-translationally modified segments of microtubules.

https://www.ncbi.nlm.nih.gov/pubmed/17846175