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© Institut Pasteur/Perrine Bomme, Nouara Lhocine et Jean-Marc Panaud
Salmonella in scanning electron microscopy (bacillus in red), bacterium responsible for foodborne infections.
Publication : Biotechnology reports (Amsterdam, Netherlands)

Isolation by Miniaturized Culture Chip of an Antarctic bacterium sp. with antimicrobial and anthelmintic activity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biotechnology reports (Amsterdam, Netherlands) - 06 Sep 2018

Palma Esposito F, Ingham CJ, Hurtado-Ortiz R, Bizet C, Tasdemir D, de Pascale D

Link to Pubmed [PMID] – 30225207

Biotechnol Rep (Amst) 2018 Dec;20:e00281

Microbes are prolific sources of bioactive molecules; however, the cultivability issue has severely hampered access to microbial diversity. Novel secondary metabolites from as-yet-unknown or atypical microorganisms from extreme environments have realistic potential to lead to new drugs with benefits for human health. Here, we used a novel approach that mimics the natural environment by using a Miniaturized Culture Chip allowing the isolation of several bacterial strains from Antarctic shallow water sediments under near natural conditions. A Gram-negative Antarctic bacterium belonging to the genus was subjected to further analyses. The sp. genome was sequenced and a bioinformatic approach was applied to identify biosynthetic gene clusters. The extract of the sp. showed antimicrobial and anthelmintic activity towards Multidrug resistant bacteria and the nematode . This is the first multi-approach study exploring the genomics and biotechnological potential of the genus that is a promising candidate for pharmaceutical applications.

https://www.ncbi.nlm.nih.gov/pubmed/30225207