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© Michaela Muller-Trutwin
HIV
Publication : Current opinion in virology

Innate immune cell responses in non pathogenic versus pathogenic SIV infections

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in virology - 20 Jul 2016

Huot N, Rascle P, Garcia-Tellez T, Jacquelin B, Müller-Trutwin M

Link to Pubmed [PMID] – 27447445

Curr Opin Virol 2016 Aug;19:37-44

HIV-1/SIVmac infections deeply disturb innate host responses. Most studies have focused on the impact on dendritic cells and NK cells. A few but insufficient data are available on other innate immune cell types, such as neutrophils. It has been shown that innate lymphoid cells are depleted early and irreversibly during SIVmac/HIV-1 infections. Studies in natural hosts of SIV have contributed to pinpoint that early control of inflammation is crucial. In natural hosts, plasmacytoid dendritic cells, myeloid dendritic cells and NK cells are depleted during acute infection but return to normal levels by the end of acute infection. We summarize here the similarities and differences of various types of innate immune responses in natural hosts compared to pathogenic HIV/SIV mac infections.

https://www.ncbi.nlm.nih.gov/pubmed/27447445