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© Research
Publication : Infection and immunity

Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani

Member: Gérald Spaeth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Jan 2004

Amprey JL, Späth GF, Porcelli SA

Link to Pubmed [PMID] – 14688141

Infect. Immun. 2004 Jan;72(1):589-92

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.