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© Research
Publication : The Journal of pharmacy and pharmacology

Acute and topic anti-edematogenic fractions isolated from the seeds of Pterodon pubescens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of pharmacy and pharmacology - 01 Jan 2004

Silva MC, Gayer CR, Lopes CS, Calixto NO, Reis PA, Passaes CP, Paes MC, Dalmau SR, Sabino KC, Todeschini AR, Coelho MG

Link to Pubmed [PMID] – 14980011

J. Pharm. Pharmacol. 2004 Jan;56(1):135-41

We previously demonstrated that alcoholic extracts from Pterodon pubescens Benth. (Sucupira branca, Leguminosae) seeds exhibit anti-arthritic activity. In the present work we show that the oleaginous extract obtained from P. pubescens seeds (OEP) exhibits acute or topic anti-edematogenic activity when tested in carrageenan-induced paw edema or in croton oil-induced ear edema assays, respectively. Four fractions were obtained from OEP by sequential liquid-liquid extraction. The anti-edematogenic properties were predominant in the hexanic fraction, which was further fractionated by HPLC, yielding three sub-fractions (PF1.1, PF1.2 and PF1.3). PF1.1 and PF1.3 showed potent acute and topic anti-edematogenic activity. The PF1.2 sub-fraction, although not active in the carrageenan assay, exhibited a potent anti-edematogenic activity in the croton oil-induced ear edema. This sub-fraction shows a maximum efficacy similar to indometacin in a lower dose. The PF1.1 sub-fraction presented a complex mixture containing furane diterpene derivatives of vouacapan. PF1.2 consists of a single substance, geranylgeraniol, as determined by GC/MS and NMR, while PF1.3 contains farnesol.

http://www.ncbi.nlm.nih.gov/pubmed/14980011