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© Research
Publication : Nature communications

Indirect protection from vaccinating children against influenza in households

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 10 Jan 2019

Tsang TK, Fang VJ, Ip DKM, Perera RAPM, So HC, Leung GM, Peiris JSM, Cowling BJ, Cauchemez S

Link to Pubmed [PMID] – 30631062

Nat Commun 2019 01;10(1):106

Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized controlled trial, with one child in each household randomized to receive influenza vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy was 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members would only be reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.

https://www.ncbi.nlm.nih.gov/pubmed/30631062