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© Research
Publication : Diagnostic microbiology and infectious disease

In vitro synergy of ticarcillin/clavulanate in combination with aztreonam and ceftolozane/tazobactam against SPM-1-producing Pseudomonas aeruginosa strains.

Member: Carolina Nodari
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Diagnostic microbiology and infectious disease - 01 Jun 2021

Rocha-Santos G, Cuba GT, Cayô R, Streling AP, Nodari CS, Gales AC, Pignatari ACC, Nicolau DP, Kiffer CRV,

Link to Pubmed [PMID] – 33652305

Link to DOI – S0732-8893(21)00036-510.1016/j.diagmicrobio.2021.115343

Diagn Microbiol Infect Dis 2021 Jun; 100(2): 115343

Minimal inhibitory concentrations (MICs) of ticarcillin/clavulanic acid (TLc), ceftolozane/tazobactam (C/T), and aztreonam (AT) were determined for 6 SPM-1-producing Pseudomonas aeruginosa (PSA) using Etest® strips and the synergistic effect of such antimicrobials against was evaluated by gradient diffusion strip crossing (GDSC) test. The fraction inhibitory concentration indexes (FICI) were calculated and showed a synergistic (n = 3) and additive (n = 2) effects of TLc + AT against SPM-1 producers, while TLc + C/T combination caused no effect. Average MIC reduction of TLc and AT by GDSC was 3-fold and 2-fold dilutions, respectively. Thus, TLc + AT might be a candidate as a combination therapy to treat SPM-1-producing PSA infections.