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© Research
Publication : Antimicrobial agents and chemotherapy

In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp

Team: Archived: Molecular Mycology
Team: Fungal Biology and Pathogenicity
Member: Alexandre Alanio
Member: Olivier Lortholary
Member: Marie-Elisabeth Bougnoux
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 21 May 2012

Planche V, Ducroz S, Alanio A, Bougnoux ME, Lortholary O, Dannaoui E

Link to Pubmed [PMID] – 22615296

Antimicrob. Agents Chemother. 2012 Aug;56(8):4500-3

In vitro interaction of anidulafungin with voriconazole was tested by a microdilution broth checkerboard technique and an agar diffusion method against 30 Aspergillus clinical isolates belonging to five different species. By using a complete inhibition endpoint, indifferent interactions were observed for 97% of the isolates by the checkerboard technique (FIC index from 0.5 to 2) and for 100% of the isolates by the agar diffusion method (variation of -2 to +1 log(2) dilutions).