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© Research
Publication : International journal of antimicrobial agents

Implementation and impact of an audit and feedback antimicrobial stewardship intervention in the orthopaedics department of a tertiary-care hospital: a controlled interrupted time series study

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of antimicrobial agents - 12 Jan 2018

Tavares M, Carvalho AC, Almeida JP, Andrade P, São-Simão R, Soares P, Alves C, Pinto R, Fontanet A, Watier L

Link to Pubmed [PMID] – 29339298

Int. J. Antimicrob. Agents 2018 Jun;51(6):925-931

A prospective audit and feedback antimicrobial stewardship intervention conducted in the Orthopaedics Department of a university hospital in Portugal was evaluated by comparing an interrupted time series in the intervention group with a non-intervention (control) group. Monthly antibiotic use (except cefazolin) was measured as the World Health Organization’s Anatomical Therapeutic Chemical defined daily doses (ATC-DDD) from January 2012 to September 2016, excluding the 6-month phase of intervention implementation starting on 1 January 2015. Compared with the control group, the intervention group had a monthly decrease in the use of fluoroquinolones by 2.3 DDD/1000 patient-days [95% confidence interval (CI) -3.97 to -0.63]. An increase in the use of penicillins by 103.3 DDD/1000 patient-days (95% CI 47.42 to 159.10) was associated with intervention implementation, followed by a decrease during the intervention period (slope = -5.2, 95% CI -8.56 to -1.82). In the challenging scenario of treatment of osteoarticular and prosthetic joint infections, an audit and feedback intervention reduced antibiotic exposure and spectrum.

https://www.ncbi.nlm.nih.gov/pubmed/29339298