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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Journal of immunology (Baltimore, Md. : 1950)

IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 15 Sep 1999

Gerber DJ, Azuara V, Levraud JP, Huang SY, Lembezat MP, Pereira P

Link to Pubmed [PMID] – 10477572

J. Immunol. 1999 Sep;163(6):3076-82

IL-4-producing gamma delta thymocytes in normal mice belong to a distinct subset of gamma delta T cells characterized by low expression of Thy-1. This gamma delta thymocyte subset shares a number of phenotypic and functional properties with the NK T cell population. Thy-1dull gamma delta thymocytes in DBA/2 mice express a restricted repertoire of TCRs that are composed of the V gamma 1 gene product mainly associated with the V delta 6.4 chain and exhibit limited junctional sequence diversity. Using mice transgenic for a rearranged V gamma 1J gamma 4C gamma 4 chain and a novel mAb (9D3) specific for the V delta 6.3 and V delta 6.4 murine TCR delta chains, we have analyzed the peripheral localization and functional properties of gamma delta T cells displaying a similarly restricted TCR repertoire. In transgenic mice, IL-4 production by peripheral gamma delta T cells was confined to the gamma delta+9D3+ subset, which contains cells with a TCR repertoire similar to that found in Thy-1dull gamma delta thymocytes. In normal DBA/2 mice such cells represent close to half of the gamma delta T cells present in the liver and around 20% of the splenic gamma delta T cells.

http://www.ncbi.nlm.nih.gov/pubmed/10477572