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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : FEMS microbiology letters

IHF is a trans-acting factor implicated in the regulation of the proU P2 promoter

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEMS microbiology letters - 22 Dec 2014

Khodr A, Fairweather V, Bouffartigues E, Rimsky S

Link to Pubmed [PMID] – 25673659

FEMS Microbiol. Lett. 2015 Jan;362(3):1-6

IHF is a protein of the bacterial nucleoid proteins (NAPs for nucleoid-associated proteins) involved in DNA structuring and transcription regulation. In vivo interplay between different NAPs determines selectively the expression rate of many genes. Here, we show that IHF is a trans-acting factor implicated directly in the regulation of the proU promoter of Escherichia coli by binding specifically and solely around the promoter box. proU expression is mainly under the repression effect of another NAP, H-NS. We show that IHF binding to proU organize the promoter DNA local structure in a completely different way than H-NS binding. Thus, we propose that the partial alleviation of H-NS repression is mediated by the promoter structure modification.

https://www.ncbi.nlm.nih.gov/pubmed/25673659