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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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CV

My research started in 1981 in the Unité de Biochimie Cellulaire directed by Georges Cohen (Institut Pasteur, Paris), where I worked on the branched biosynthetic pathway leading to the amino acids Lys, Met, Thr and Ile; we found that enzymes catalyzing different steps in this pathway have a common origin, thereby providing evidence that amino acid biosynthetic pathways have been constructed by specialization of enzymes exhibiting a substrate ambiguity.

In 1988, I joined the laboratory of John Mekalanos (Harvard Medical School, Boston), where I studied for two years the regulation of virulence genes in Vibrio cholerae; we performed a functional analysis of genes co-regulated with cholera toxin-encoding genes and demonstrated a regulatory cascade controlling their expression.

In 1990, I joined the newly created Unité de Pathogénie Microbienne Moléculaire directed by Philippe Sansonetti (Institut Pasteur, Paris), where I investigated virulence factors of Shigella flexneri. Over the last 20 years, I headed a group composed of one or two PhD students, a post-doctoral fellow and, since 2003, a technician. Our works participated to the discovery of the type III secretion (T3S) pathway used by many Gram-negative bacteria to inject effector proteins into host cells and alter their signaling pathways.

From January 2010 to December 2014, I occupied the function of Vice-President for Teaching at Institut Pasteur.

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