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© Research
Publication : Cell host & microbe

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Team: Innate Immunity
Team: Group: Humanized mice for infectious disease modeling
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell host & microbe - 23 Jul 2009

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P

Link to Pubmed [PMID] – 19616761

Cell Host Microbe 2009 Jul;6(1):5-9

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.