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© Research
Publication : Nature Communications

Targets of complement-fixing antibodies in protective immunity against malaria in children

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Communications - 05 Feb 2019

Reiling L, Boyle MJ, White MT, Wilson DW, Feng G, Weaver R, Opi DH, Persson KEM, Richards JS, Siba PM, Fowkes FJ, Takashima E, Tsuboi T, Mueller I, Beeson JG

Link to Pubmed [PMID] – 30723225

Nat Commun. 2019 Feb 5;10(1):610

Antibodies against Pfalciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-induced immunity; however, specific targets of these functional antibodies and their importance in protective immunity are unknown. Among malaria-exposed individuals, we show that complement-fixing antibodies to merozoites are more strongly correlated with protective immunity than antibodies that inhibit growth quantified using the current reference assay for merozoite vaccine evaluation. We identify merozoite targets of complement-fixing antibodies and identify antigen-specific complement-fixing antibodies that are strongly associated with protection from malaria in a longitudinal study of children. Using statistical modelling, combining three different antigens targeted by complement-fixing antibodies could increase the potential protective effect to over 95%, and we identify antigens that were common in the most protective combinations. Our findings support antibody-complement interactions against merozoite antigens as important anti-malaria immune mechanisms, and identify specific merozoite antigens for further evaluation as vaccine candidates.

https://www.nature.com/articles/s41467-019-08528-z