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© Research
Publication : Mammalian genome : official journal of the International Mammalian Genome Society

Host genetic control of mosquito-borne Flavivirus infections.

Team: Ecology and Emergence of Arthropod-borne Pathogens
Team: Mouse Genetics
Member: Tineke Cantaert
Member: Xavier Montagutelli
Member: Anavaj Sakuntabhai
Member: Claude Roth
Member: Caroline Manet
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mammalian genome : official journal of the International Mammalian Genome Society - 01 Aug 2018

Manet C, Roth C, Tawfik A, Cantaert T, Sakuntabhai A, Montagutelli X,

Link to Pubmed [PMID] – 30167843

Link to DOI – 10.1007/s00335-018-9775-2

Mamm Genome 2018 08; 29(7-8): 384-407

Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants, the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans.