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© Research
Publication : Trends in cell biology

Homologous Recombination and the Formation of Complex Genomic Rearrangements

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in cell biology - 26 Nov 2018

Piazza A, Heyer WD

Link to Pubmed [PMID] – 30497856

Trends Cell Biol. 2019 Feb;29(2):135-149

The maintenance of genome integrity involves multiple independent DNA damage avoidance and repair mechanisms. However, the origin and pathways of the focal chromosomal reshuffling phenomena collectively referred to as chromothripsis remain mechanistically obscure. We discuss here the role, mechanisms, and regulation of homologous recombination (HR) in the formation of simple and complex chromosomal rearrangements. We emphasize features of the recently characterized multi-invasion (MI)-induced rearrangement (MIR) pathway which uniquely amplifies the initial DNA damage. HR intermediates and cellular contexts that endanger genomic stability are discussed as well as the emerging roles of various classes of nucleases in the formation of genome rearrangements. Long-read sequencing and improved mapping of repeats should enable better appreciation of the significance of recombination in generating genomic rearrangements.

https://www.ncbi.nlm.nih.gov/pubmed/30497856