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Deputy Director of National Reference Center
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Archaeal phylogeny based on proteins of the transcription and translation machineries: tackling the Methanopyrus kandleri paradox

The Erp protein is anchored at the surface by a carboxy-terminal hydrophobic domain and is important for cell-wall structure in Mycobacterium smegmatis

© Research

Publication : AIDS (London, England)

HIV infection: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment

Team: Epidemiology of Emerging Diseases

Member: Arnaud Fontanet

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in AIDS (London, England) - 20 Feb 2004

Beq S, Rannou MT, Fontanet A, Delfraissy JF, Thèze J, Colle JH

Link to Pubmed [PMID] – 15090811

AIDS 2004 Feb;18(3):563-5

Highly active antiretroviral therapy (HAART) in HIV patients generally increases the CD4 cell count, but the level of CD4 cell restoration remains very heterogeneous. IL-7 is the main cytokine controlling the size of the T-cell pool. We assessed the hypothesis that pre-HAART IL-7 plasma levels may affect CD4 cell restoration after treatment. A positive correlation was found in a cohort of 18 patients between pre-HAART IL-7 plasma levels and CD4 cell increases after 20 +/- 7.8 months of HAART.

Published on: 20 Feb 2004