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© Research
Publication : PloS one

HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients

Team: Archived: Molecular Mycology
Member: Olivier Lortholary
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 30 Nov 2012

Abravanel F, Raymond S, Pambrun E, Winnock M, Bonnard P, Sogni P, Trimoulet P, Dabis F, Salmon-Ceron D, Izopet J,

Link to Pubmed [PMID] – 23226258

PLoS ONE 2012;7(11):e50289

Hepatic stellate cells, the major producers of extracellular matrix in the liver, and hepatocytes bear CXCR4 and CCR5, the two main co-receptors for entry of the human immunodeficiency virus (HIV). In vitro studies suggest that HIV-envelope proteins can modulate the replication of hepatitis C virus (HCV) and fibrogenesis. We investigated the influence of HIV tropism on liver fibrosis and the concentration of HCV RNA in HIV-HCV co-infected patients.