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© Research
Publication : Nature structural & molecular biology

Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature structural & molecular biology - 27 Feb 2011

Saint-André V, Batsché E, Rachez C, Muchardt C

Link to Pubmed [PMID] – 21358630

Nat. Struct. Mol. Biol. 2011 Mar;18(3):337-44

Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore conceivable that chromatin-borne information participates in alternative splicing. Here we find that elevated levels of trimethylation of histone H3 on Lys9 (H3K9me3) are a characteristic of the alternative exons of several genes including CD44. On this gene the chromodomain protein HP1γ, frequently defined as a transcriptional repressor, facilitates inclusion of the alternative exons via a mechanism involving decreased RNA polymerase II elongation rate. In addition, accumulation of HP1γ on the variant region of the CD44 gene stabilizes association of the pre-mRNA with the chromatin. Altogether, our data provide evidence for localized histone modifications impacting alternative splicing. They further implicate HP1γ as a possible bridging molecule between the chromatin and the maturating mRNA, with a general impact on splicing decisions.

https://www.ncbi.nlm.nih.gov/pubmed/21358630