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© Michaela Muller-Trutwin
HIV
Publication : European journal of immunology

High proportion of PD-1-expressing CD4(+) T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Aug 2017

Damouche A, Pourcher G, Pourcher V, Benoist S, Busson E, Lataillade JJ, Le Van M, Lazure T, Adam J, Favier B, Vaslin B, Müller-Trutwin M, Lambotte O, Bourgeois C

Link to Pubmed [PMID] – 28762530

Eur. J. Immunol. 2017 Aug;

We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of reducing these reservoirs. Here, we evaluated the immune characteristics of adipose tissue in HIV-infected patients receiving antiretroviral therapy (ART) and in non-HIV-infected patients. We notably sought to determine whether adipose tissue’s intrinsic properties and/or HIV induced alteration of the tissue environment may favour viral persistence. ART-controlled HIV infection was associated with a difference in the CD4/CD8 T-cell ratio and an elevated proportion of Treg cells in subcutaneous adipose tissue. No changes in Th1, Th2 and Th17 cell proportions or activation markers expression on T cell (Ki-67, HLA-DR) could be detected, and the percentage of CD69-expressing resident memory CD4(+) T cells was not affected. Overall, our results indicate that adipose-tissue-resident CD4(+) T cells are not extensively activated during HIV infection. PD-1 was expressed by a high proportion of tissue-resident memory CD4(+) T cells in both HIV-infected patients and non-HIV-infected patients. Our findings suggest that adipose tissue’s intrinsic immunomodulatory properties may limit immune activation and thus may strongly contribute to viral persistence.

https://www.ncbi.nlm.nih.gov/pubmed/28762530