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© Research
Publication : Current topics in microbiology and immunology

GPI Anchored Proteins in Aspergillus fumigatus and Cell Wall Morphogenesis.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current topics in microbiology and immunology - 01 Jan 2020

Samalova M, Carr P, Bromley M, Blatzer M, Moya-Nilges M, Latgé JP, Mouyna I,

Link to Pubmed [PMID] – 32418035

Link to DOI [DOI] – 10.1007/82_2020_207

Curr Top Microbiol Immunol 2020 ; 425(): 167-186

Glycosylphosphatidylinositol (GPI) anchored proteins are a class of proteins attached to the extracellular leaflet of the plasma membrane via a post-translational modification, the glycolipid anchor. GPI anchored proteins are expressed in all eukaryotes, from fungi to plants and animals. They display very diverse functions ranging from enzymatic activity, signaling, cell adhesion, cell wall metabolism, and immune response. In this review, we investigated for the first time an exhaustive list of all the GPI anchored proteins present in the Aspergillus fumigatus genome. An A. fumigatus mutant library of all the genes that encode in silico identified GPI anchored proteins has been constructed and the phenotypic analysis of all these mutants has been characterized including their growth, conidial viability or morphology, adhesion and the ability to form biofilms. We showed the presence of different fungal categories of GPI anchored proteins in the A. fumigatus genome associated to their role in cell wall remodeling, adhesion, and biofilm formation.

https://pubmed.ncbi.nlm.nih.gov/32418035