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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Acta tropica

Genetic diversity and genotype multiplicity of Plasmodium falciparum infections in symptomatic individuals living in Bangui (CAR)

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Acta tropica - 18 Apr 2008

Dolmazon V, Matsika-Claquin MD, Manirakiza A, Yapou F, Nambot M, Menard D

Link to Pubmed [PMID] – 18501320

Acta Trop. 2008 Jul;107(1):37-42

This study provides the first estimate of the genetic diversity and genotype multiplicity of Plasmodium falciparum infections in symptomatic individuals living in Bangui (Central African Republic, CAR). Three hundred thirty six clinical isolates were used for analysis of parasite population polymorphism and genotyped by nested-PCR of msp-1 block 2, and msp-2 block 3. We found a very high level of polymorphism, with, respectively, 17 and 25 different alleles at the msp-1 and msp-2 loci and a high percentage of multiclonal infections (42.7% with msp-1 and 76.7% with msp-2), with a mean of 1.7 genotype with msp-1 and 2.8 with msp-2. We observed that (i) multiclonal infections and allelic polymorphism of msp-2 were significantly more frequent in Southern districts than in Northern districts of Bangui suggesting that the epidemiological features of P. falciparum may vary within Bangui and (ii) showed that immunocompromised HIV-positive patients tend to have a lower average number of msp-2 allele per isolate than immunocompetent patients.

https://www.ncbi.nlm.nih.gov/pubmed/18501320