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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Genetic and biochemical analysis of development in Toxoplasma gondii

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Sep 1997

Boothroyd JC, Black M, Bonnefoy S, Hehl A, Knoll LJ, Manger ID, Ortega-Barria E, Tomavo S

Link to Pubmed [PMID] – 9355126

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1997 Sep;352(1359):1347-54

Toxoplasma gondii has recently come under intense study as a model for intracellular parasitism because it has a number of properties that facilitate experimental manipulation. Attention is now being turned towards understanding the developmental biology of this complex parasite. The differentiation between the two asexual stages, the rapidly growing tachyzoites and the more slowly dividing, encysted bradyzoites, is of particular interest. Progression from the former to the latter is influenced by the host’s immune response. This paper describes current progress on a number of research fronts, all aimed at understanding the triggers that push the tachyzoite-bradyzoite equilibrium in one or other direction and the changes that occur in gene expression (and ultimately metabolism and function). Chief among the techniques used for these studies are genetics and molecular genetics. Recent progress in these areas is described.

http://www.ncbi.nlm.nih.gov/pubmed/9355126