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© Research
Publication : Transplant immunology

Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transplant immunology - 23 Oct 2012

Angin M, Poirier N, Dilek N, Le Guiner C, Toromanoff A, Blancher A, Cherel Y, Deschamps JY, Tillou X, Renaudin K, Minault D, Hervouet J, Blancho G, Vanhove B, Anegon I, Le Mauff B

Link to Pubmed [PMID] – 23098770

Transpl. Immunol. 2012 Dec;27(4):139-45

Blockade of costimulation signaling required for immune response, such as CD40/CD40L and CD28/B7, is a reasonable strategy to prevent rejection and in defined combinations may allow donor specific tolerance. Indeed, in rodents, costimulation blockade with CD28/B7 antagonists or with CD40Ig was able to induce regulatory T cells and transplant tolerance whereas in primates, anti-CD40 antibodies, anti-CD40L antibodies or CTLA4Ig, used as monotherapy, significantly delayed graft rejection.

http://www.ncbi.nlm.nih.gov/pubmed/23098770