Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model

Lien vers Pubmed [PMID] – 23098770

Transpl. Immunol. 2012 Dec;27(4):139-45

Blockade of costimulation signaling required for immune response, such as CD40/CD40L and CD28/B7, is a reasonable strategy to prevent rejection and in defined combinations may allow donor specific tolerance. Indeed, in rodents, costimulation blockade with CD28/B7 antagonists or with CD40Ig was able to induce regulatory T cells and transplant tolerance whereas in primates, anti-CD40 antibodies, anti-CD40L antibodies or CTLA4Ig, used as monotherapy, significantly delayed graft rejection.