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© Research
Publication : Immunity

GATA-3 function in innate and adaptive immunity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunity - 21 Aug 2014

Tindemans I, Serafini N, Di Santo JP, Hendriks RW

Link to Pubmed [PMID] – 25148023

Immunity 2014 Aug;41(2):191-206

The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and function. Furthermore, during thymopoiesis, GATA-3 represses B cell potential in early T cell precursors, activates TCR signaling in pre-T cells, and promotes the CD4(+) T cell lineage after positive selection. GATA-3 also functions outside the thymus in hematopoietic stem cells, regulatory T cells, CD8(+) T cells, thymic natural killer cells, and ILC precursors. Here we discuss the varied functions of GATA-3 in innate and adaptive immune cells, with emphasis on its activity in T cells and ILCs, and examine the mechanistic basis for the dose-dependent, developmental-stage- and cell-lineage-specific activity of this transcription factor.

http://www.ncbi.nlm.nih.gov/pubmed/25148023