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© Research
Publication : Mycologia

Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer

Member: Thierry Fontaine
Member: Jean-Paul Latge
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mycologia - 01 Mar 2016

Briard B, Muszkieta L, Latgé JP, Fontaine T

Link to Pubmed [PMID] – 26932183

Mycologia, 2016 May-Jun;108(3):572-80.

Galactosaminogalactan (GAG) is an extracellular polysaccharide produced by the mycelium of the opportunistic human fungal pathogen Aspergillus fumigatus. GAG is the first polysaccharide described as a virulence factor in medical mycology. This review presents our current knowledge of the structural organization and biosynthesis of this polymer. The function of this molecule as an adhesin that also masks Aspergillus PAMPs and the impact of GAG on the modulation of the host immune response by inducing neutropenia and blocking the IL-1 signaling pathway also will be emphasised.