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© Research
Publication : Current opinion in microbiology

Functional duality of the cell wall

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 14 Jun 2014

Latgé JP, Beauvais A

Link to Pubmed [PMID] – 24937317

Curr. Opin. Microbiol. 2014 Aug;20:111-7

The polysaccharide cell wall is the extracellular armour of the fungal cell. Although essential in the protection of the fungal cell against aggressive external stresses, the biosynthesis of the polysaccharide core is poorly understood. For a long time it was considered that this cell wall skeleton was a fixed structure whose role was only to be sensed as non-self by the host and consequently trigger the defence response. It is now known that the cell wall polysaccharide composition and localization continuously change to adapt to their environment and that these modifications help the fungus to escape from the immune system. Moreover, cell wall polysaccharides could function as true virulence factors.

http://www.ncbi.nlm.nih.gov/pubmed/24937317