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© Research
Publication : The Journal of molecular and cellular immunology : JMCI

Functional and biochemical evidence for the recognition of T cell receptors by monoclonal antibodies to an immunoglobulin idiotype

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of molecular and cellular immunology : JMCI - 01 Jan 1986

Martínez C, Bragado R, de la Hera A, Toribio ML, Marcos MA, Bandeira A, Pereira P, Coutinho A

Link to Pubmed [PMID] – 2978235

J. Mol. Cell. Immunol. 1986;2(6):307-13

Sharing of “idiotypes” by T and B cells with similar nominal specificities has been extensively reported in functional assays. The recent molecular characterization of T cell receptors has led to the suggestion that such idiotypic mimicries could result from “network” selection of available T cell repertoires. Alternatively, the validity of the conclusions taken from those functional assays could be questioned. We have now used an experimental system where recurrent expression of antibody idiotypes by T helper cells requires “learning” from the B cell/antibody compartment, and show here that the idiotypic determinants in question are indeed associated with T cell receptor molecules. A monoclonal antibody (F6(51)) directed to an idiotope of the TNP-binding BALB/c myeloma protein MOPC460 specifically inhibits antigen-dependent proliferation and helper activity of BALB/c anti-TNP-BALB/c helper T cells. The anti-idiotypic antibodies also induce IL-2 production by these helper cells and precipitate a surface molecule with characteristics of T cell receptor. We conclude that, in this particular system, T cell receptors and antibodies of similar nominal specificities share idiotypic determinants.

http://www.ncbi.nlm.nih.gov/pubmed/2978235