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© Research
Publication : Antimicrobial agents and chemotherapy

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 28 Sep 2015

Valsecchi I, Mellado E, Beau R, Raj S, Latgé JP

Link to Pubmed [PMID] – 26416854

Antimicrob. Agents Chemother. 2015 Dec;59(12):7866-9

Isogenic bar-coded strains of Aspergillus fumigatus carrying the G54W or M220K mutation in Cyp51A were constructed. In vitro, the growth and conidiation capacities of the mutants were similar to those of the parental strain. Competition studies in the absence of azoles showed that there was no adverse fitness cost for the azole-resistant A. fumigatus strains in vitro or in vivo compared to the parental strain.

https://www.ncbi.nlm.nih.gov/pubmed/26416854