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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Transactions of the Royal Society of Tropical Medicine and Hygiene

First evidence of pfcrt mutant Plasmodium falciparum in Madagascar

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transactions of the Royal Society of Tropical Medicine and Hygiene - 26 Jan 2006

Randrianarivelojosia M, Fidock DA, Belmonte O, Valderramos SG, Mercereau-Puijalon O, Ariey F

Link to Pubmed [PMID] – 16442577

Trans. R. Soc. Trop. Med. Hyg. 2006 Sep;100(9):826-30

The island of Madagascar, lying in the Indian Ocean approximately 250 miles from the African coast, has so far remained one of the few areas in the world without noticeable Plasmodium falciparum high-grade chloroquine (CQ) resistance. Here we report genotyping data on pfcrt in Madagascar. The pfcrt K76T mutation, which is critical for resistance to CQ, was detected in six (3.3%) of 183 P. falciparum isolates screened, within the mutant haplotypes CVIET and CVIDT. This is the first observation of pfcrt mutant parasites on the island. The current massive distribution of CQ for in-home management of fever in children will promote the dissemination of these mutant CQ-resistant parasites. In this context, genotyping of pfcrt remains a useful tool for CQ resistance surveillance as the prevalence of pfcrt mutations is far from saturation in Madagascar.

http://www.ncbi.nlm.nih.gov/pubmed/16442577