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© Research
Publication : Sub-cellular biochemistry

Exploring the Protein Folding Pathway with High-Pressure NMR: Steady-State and Kinetics Studies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Sub-cellular biochemistry - 01 Jan 2015

Roche J, Dellarole M, Royer CA, Roumestand C

Link to Pubmed [PMID] – 26174386

Subcell. Biochem. 2015;72:261-78

Defining the physical-chemical determinants of protein folding and stability, under normal and pathological conditions has constituted a major subfield in biophysical chemistry for over 50 years. Although a great deal of progress has been made in recent years towards this goal, a number of important questions remain. These include characterizing the structural, thermodynamic and dynamic properties of the barriers between conformational states on the protein energy landscape, understanding the sequence dependence of folding cooperativity, defining more clearly the role of solvation in controlling protein stability and dynamics and probing the high energy thermodynamic states in the native state basin and their role in misfolding and aggregation. Fundamental to the elucidation of these questions is a complete thermodynamic parameterization of protein folding determinants. In this chapter, we describe the use of high-pressure coupled to Nuclear Magnetic Resonance (NMR) spectroscopy to reveal unprecedented details on the folding energy landscape of proteins.

http://www.ncbi.nlm.nih.gov/pubmed/26174386