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© Mart Krupovic, Junfeng Liu
Scanning electron micrograph of Saccharolobus islandicus cells (light blue) infected with the lemon-shaped virus STSV2 (yellow). Artistic rendering by Ala Krupovic.
Publication : Cell

Expansion of the global RNA virome reveals diverse clades of bacteriophages

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell - 13 Oct 2022

Neri U, Wolf YI, Roux S, Camargo AP, Lee B, Kazlauskas D, Chen IM, Ivanova N, Zeigler Allen L, Paez-Espino D, Bryant DA, Bhaya D, RNA Virus Discovery Consortium, Krupovic M, Dolja VV, Kyrpides NC, Koonin EV, Gophna U

Link to Pubmed [PMID] – 36174579

Link to DOI – 10.1016/j.cell.2022.08.023S0092-8674(22)01118-7

Cell 2022 Oct; 185(21): 4023-4037.e18

High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA virome. Mining 5,150 diverse metatranscriptomes uncovered >2.5 million RNA virus contigs. Analysis of >330,000 RNA-dependent RNA polymerases (RdRPs) shows that this expansion corresponds to a 5-fold increase of the known RNA virus diversity. Gene content analysis revealed multiple protein domains previously not found in RNA viruses and implicated in virus-host interactions. Extended RdRP phylogeny supports the monophyly of the five established phyla and reveals two putative additional bacteriophage phyla and numerous putative additional classes and orders. The dramatically expanded phylum Lenarviricota, consisting of bacterial and related eukaryotic viruses, now accounts for a third of the RNA virome. Identification of CRISPR spacer matches and bacteriolytic proteins suggests that subsets of picobirnaviruses and partitiviruses, previously associated with eukaryotes, infect prokaryotic hosts.

https://pubmed.ncbi.nlm.nih.gov/36174579