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© Mart Krupovic, Junfeng Liu
Scanning electron micrograph of Saccharolobus islandicus cells (light blue) infected with the lemon-shaped virus STSV2 (yellow). Artistic rendering by Ala Krupovic.
Publication : Nature Microbiology

Evolutionary diversification of methanotrophic ANME-1 archaea and their expansive virome

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Microbiology - 19 Jan 2023

Laso-Pérez R*, Wu F*, Crémière A, Speth DR, Magyar JS, Zhao K, Krupovic M*, Orphan VJ*

Link to Pubmed [PMID] – 36658397

Link to DOI – 10.1038/s41564-022-01297-4

Nat Microbiol 2023 Jan; In press

‘Candidatus Methanophagales’ (ANME-1) is an order-level clade of archaea responsible for anaerobic methane oxidation in deep-sea sediments. The diversity, ecology and evolution of ANME-1 remain poorly understood. In this study, we use metagenomics on deep-sea hydrothermal samples to expand ANME-1 diversity and uncover the effect of virus-host dynamics. Phylogenetic analyses reveal a deep-branching, thermophilic family, ‘Candidatus Methanospirareceae’, closely related to short-chain alkane oxidizers. Global phylogeny and near-complete genomes show that hydrogen metabolism within ANME-1 is an ancient trait that was vertically inherited but differentially lost during lineage diversification. Metagenomics also uncovered 16 undescribed virus families so far exclusively targeting ANME-1 archaea, showing unique structural and replicative signatures. The expansive ANME-1 virome contains a metabolic gene repertoire that can influence host ecology and evolution through virus-mediated gene displacement. Our results suggest an evolutionary continuum between anaerobic methane and short-chain alkane oxidizers and underscore the effects of viruses on the dynamics and evolution of methane-driven ecosystems.

https://pubmed.ncbi.nlm.nih.gov/36658397